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Contact information Lawrence Livermore National Laboratory Bulding 242, Room 2212 |
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Education
MCS, Numerical Analysis, University of Illinois Urbana Champaign, IL
BS, Mathematics and Computer Science, Tulane University, LA
Research
I develop novel numerical methods and new software toolchains for conducting clinically-relevant cardiac electrophysiological/electromechanical cardiac simulations. My interests include high throughput in-silico drug screening, cardiac device testing and validation, and image-based simulations of individual patient etiologies.
Selected Publications
J. Molitoris, S. Paliwal, R. Sekar, R. Blake, J. Park, N. Trayanova, L. Tung, A. Levchenko. Precisely parameterized experimental and computational models of tissue organization. Integr Biol (Camb). 29 Jan 2016.
S. Land, V. Gurev, S. Arens, C. Augustin, L. Baron, R. Blake, C. Bradley, S. Castro, A. Crozier, M. Favino, T. Fastl, T. Fritz, H. Gao, A. Gizzi, B. Griffith, D. Hurtado, R. Krause, X. Luo, M. Nash, S. Pezzuto, G. Plank, S. Rossi, D. Ruprecht, G. Seemann, N. Smith, J. Sundnes, J. Rice, N. Trayanova, D. Wang, Z. Jenny Wang, S. Niederer. Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour. Proc Math Phys Eng Sci. 471(2184): 20150641, 8 Dec 2015.
H. Ashikaga, H. Arevalo, F. Vadakkumpadan, R. Blake, J. Bayer, S. Nazarian, M. Muz Zviman, H. Tandri, R. Berger, H. Calkins, D. Herzka, N. Trayanova, H. Halperin. Feasibility of image-based simulation to estimate ablation target in human ventricular arrhythmia. Heart Rhythm. 10(8): 1109-16, Aug 2013.
K. McDowell, F. Vadakkumpadan, R. Blake, J. Blauer, G. Plank, R. Macleod, N. Trayanova. Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation. Biophys J. 104(12): 2764-73, 18 Jun 2013.
J. Bayer, R. Blake, G. Plank, N. Trayanova. A novel rule-based algorithm for assigning myocardial fiber orientation to computational heart models. Ann Biomed Eng. 40(10): 2243-54, Oct 2012.
K. McDowell, F. Vadakkumpadan, R. Blake, J. Blauer, G. Plank, R. MacLeod, N. Trayanova. Methodology for patient-specific modeling of atrial fibrosis as a substrate for atrial fibrillation. J Electrocardiol. 45(6): 640-5, 25 Sep 2012.
T. Maharaj, R. Blake, N. Trayanova, D. Gavaghan, B. Rodriguez. The role of transmural ventricular heterogeneities in cardiac vulnerability to electric shocks. Prog Biophys Mol Biol. 96(1-3): 321-38, 5 Oct 2007.
B. Rodríguez, B. Tice, R. Blake, D. Gavaghan, N. Trayanova. Vulnerability to electric shocks in the regionally-ischemic ventricles. Conf Proc IEEE Eng Med Biol Soc. 1: 2280-3, 2006.
T. Maharaj, B. Rodriguez, R. Blake, N. Trayanova, D. Gavaghan. Transmural electrophysiological heterogeneities in action potential duration increase the upper limit of vulnerability. Conf Proc IEEE Eng Med Biol Soc. 1: 4043-6, 2006.