Brian Bennion

Contact information

Lawrence Livermore National Laboratory
7000 East Avenue, L-372
Livermore, CA 94550
email: bennion1@llnl.gov
phone: 925 422 5722
              925-423-4334
 

Education

Utah State University, Logan, UT, Chemistry, B.S., 1996
Univ. of Washington, Seattle, WA, Medicinal Chemistry, Ph.D., 2003
Lawrence Livermore National Laboratory, Chemistry, Postdoc, 2003-2006

Research

My principal research interests are small molecule-protein interactions for discovery of cancer therapeutics and chemical warfare countermeasures.

Collaborators

Fredrik Ekstrom, Sweden
Kamil Kuca, Czech Republic
Doug Cerasoli, Institute of Chemical Defense, Maryland, USA
Kit Lam, University of California Davis Cancer Center, California, USA

Publications

  1. Li B, Alonso DOV, Bennion BJ, and Daggett V. (2001) Hydrophobic Hydration is an Important Source of Elasticity in Elastin-Based Biopolymers.  J. Am. Chem. Soc 123, 11991-11998.
  2. Zou Q, Bennion BJ, Daggett V, and Murphy KP. (2002) The Molecular Mechanism of Stabilization by TMAO and its Ability to Counteract the Effects of Urea. J. Am. Chem. Soc. 124, 1192-1202.
  3. Day R, Bennion BJ, Ham S, and Daggett V. (2002) Increasing temperature accelerates protein unfolding without changing the pathway of unfolding. J. Mol. Biol., 322, 189-203.
  4. Bennion BJ, Daggett V. (2002) Protein conformation and diagnostic tests: the prion protein.Clin. Chem., 48, 2105-2114.
  5. Bennion BJ, Daggett V. (2003) The Molecular basis for the chemical denaturation of proteins by urea. PNAS, 100, 5142-5147.
  6. Bennion BJ, Daggett V. (2004) Counteraction of urea-induced protein denaturation by TMAO: A chemical chaperone at atomic resolution. PNAS, 101, 6433-6438.
  7. Bennion BJ, Demarco M, Daggett V. (2004) Preventing misfolding of the prion protein by trimethylamine N-oxide. Biochemistry, 43, 12955-12963.
  8. Bennion BJ, Cosman M, Lightstone FC, Knize MG, Montgomery JL, Bennett LM, Felton JS, Kulp KS. (2005) PhIP carcinogenicity in breast cancer: Computational and experimental evidence for competitive interactions with human estrogen receptor. Chemical Research in Toxicology 18 (10), 1528-1536.
  9. Rutherford K, Bennion BJ, Parson WW, Daggett V (2006) The 108M polymorph of human catechol o-methyltransferase is prone to deformation at physiological temperatures. Biochemistry 45 (7): 2178-2188.
  10. Beck DAC, Bennion BJ, Alonso DOV, Daggett V (2007) Simulations of macromolecules in protective and denaturing osmolytes: Properties of mixed solvent systems and their effects on water and protein structure and dynamics. Osmosensing and osmosignalling Methods in Enzymology 428, 373-397.
  11. Fattebert, J. –L, Law, R. J., Bennion, B., Lau, E. Y., Schwegler, E., Lightstone, F. C. (2009) Quantitative Assessment of Electrostatic Embedding in Density Functional Theory Calculations of Biomolecular Systems.  Journal of Chemical Theory and Computation 5, 2257-2264.
  12. Bennion, B. J., Lau, E. Y., Corning, W., Huang, P., Schwegler, E., Lightstone, F. C., (2013) Modeling the Binding of CWAs to AChE and BuChE. Military Medical Science Letters 82 (3), 102-114.
  13. Sepsova V., Karasova J., Zemek F., Bennion B.J.,  Kuca K. (2011) Oximes as Inhibitors of Acetylcholinesterase–A Structure-Activity Relationship (SAR) Study. Military Medical Science Letters 80 (4), 178-186.
  14. Sepsova V., Karasova J., Zemek F., Bennion B.J.,  Kuca K. (2013) Oximes: Inhibitors of Human Acetylcholinesterase. International Journal of Molecular Sciences 14 (8), 16882-900.
  15. Bennion B. J., London R., Hau-Riege S.Barsky D. (Submitted Sep 2013) Molecular Dynamics Simulations and Analytical Sphere Model for the Evaporation of Nanoscale Water Droplets. J. Computational and Theoretical Chemistry.
  16. Baburina I., Li H. J., Bennion B., Furey W., Jordan F. (1998) Interdomain information transfer during substrate activation of yeast pyruvate decarboxylase: The interaction-between cysteine 221 and histidine 92. Biochemistry 37 (5) 1235-1244.