Thomas O'Hara

Contact information

Lawrence Livermore National Laboratory
7000 East Avenue, L-467
Livermore, CA 94550

Bulding 242, Room 1303
email: ohara11@llnl.gov
phone: 925 423 4933
 

Education

PhD, Biomedical Engineering, Washington University, Saint Louis
MS, Biomedical Engineering, Washington University, Saint Louis
BS, Physics, Rhodes College, Memphis

Postdoctoral Training

Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University

Areas of Interest

Signaling — second messenger signaling; calcium; reactive oxygen species and cellular metabolism/energetics; apoptosis, necrosis and toxicity; membrane curvature and macromolecular complexes; transduction of biological information.

Electrophysiology — inherited channelopathies; maturation and differentiation of human fibroblast-derived stem cells; mechanisms of anti-arrhythmic drug action and drug safety; regional heterogeneities in cell type and function.

Heart Disease — electrical and anatomical remodeling in dilated and systolic cardiomyopathy; neuro-hormonal control of pacing, and heart rate variability; biological or device-based pacing therapy; conduction abnormality, infarction/fibrosis; formation of ectopy and alternans; anatomical and/or functional block, reentry and fibrillation; mechano-electrical feedback; torso modeling and ECG signature.

Meta-Modeling — relational grounding and model scoping; model validation and quantification of biological uncertainty; parameter sensitivity.

Computation — massive parallelization; visualization of hyper-dimensional and complex data/information; workflow design and simplification

Publications

Junjie Zhang, Frédéric Sacher, Kurt Hoffmayer, Thomas O’Hara, Maria Strom, Phillip Cuculich, Jennifer Silva, Daniel Cooper, Mitchell Faddis, Mélèze Hocini, Michel Haïssaguerre, Melvin Scheinman, and Yoram Rudy, “Cardiac Electrophysiologic Substrate Underlying the ECG Phenotype and Electrogram Abnormalities in Brugada Syndrome Patients” Circulation 2015 Mar 25

Béziau DM, Barc J, O'Hara T, Le Gloan L, Amarouch MY, Solnon A, Pavin D, Lecointe S, Bouillet P, Gourraud JB, Guicheney P, Denjoy I, Redon R, Mabo P, le Marec H, Loussouarn G, Kyndt F, Schott JJ, Probst V, Baró I., “Complex Brugada syndrome inheritance in a family harbouring compound SCN5A and CACNA1C mutations” Basic Res Cardiol 2014 Nov;109(6):446.

Wright PT, Nikolaev VO, O'Hara T, Diakonov I, Bhargava A, Tokar S, Schobesberger S, Shevchuk A, Sikkel MB, Wilkinson R, Trayanova NA, Lyon AR, Harding SE, Gorelik J, “Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling” J Mol Cell Cardiol 2014 Feb;67:38-48.

NA Trayanova, T O’Hara, JD Bayer, PM Boyle, KS McDowell, J Constantino, HJ Arevalo, Y Hu, F Vadakkumpadan, “Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones” Europace 2012;14:v82-v89.

Thomas O'Hara, Yoram Rudy, “Quantitative Comparison of Cardiac Ventricular Myocyte Electrophysiology and Response to Drugs in Human and Non-Human Species” Am J Physiol Heart Circ Physiol 302: H1023–H1030, 2012.

Thomas O'Hara, Yoram Rudy, “Arrhythmia Formation in Subclinical (“Silent”) Long QT Syndrome Requires Multiple Insults: Quantitative Mechanistic Study Using the KCNQ1 Mutation Q357R as Example” Heart Rhythm 2012;9:275–282.

Thomas O'Hara, Yoram Rudy, “Arrhythmia Formation in Subclinical (“Silent”) Long QT Syndrome Requires Multiple Insults: Quantitative Mechanistic Study Using the KCNQ1 Mutation Q357R as Example” Heart Rhythm 2012;9:275–282.

Thomas O'Hara, Láslo Virág, András Varró, Yoram Rudy, “Simulation of the undiseased human cardiac ventricular action potential: Model formulation and experimental validation” PLoS Comput Biol 2011; 7(5): e1002061.

Sale H§, Wang J§, O'Hara TJ§, Tester DJ, Phartiyal P, He JQ, Rudy Y, Ackerman MJ, Robertson GA, (§ equal contribution), “Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome”, Circ Res. 2008 Sep 26;103(7):e81-95.

Bébarová M§, O'Hara T§, Geelen JL, Jongbloed RJ, Timmermans C, Arens YH, Rodriguez LM, Rudy Y, Volders PG, (§ equal contribution), “Subepicardial phase-0 block and discontinuous transmural conduction underlie right-precordial ST- segment elevation by a SCN5A loss-of-function mutation”, Am J Physiol Heart Circ Physiol. 2008;295:H48-H58.

O'Hara T, Decker K, Faber G, Livshitz L, Silva J, Rudy Y, “Comments on: ‘Role of individual ionic current systems in ventricular cells hypothesized by a model study’ by Matsuoka S, Sarai N, Kuratomi S, Ono K, and Noma A. Jpn J Physiol 53: 105-123, 2003” Jpn J Physiol. 2004 Oct;54(5):505-7; author reply 507-8.