Tim Carpenter

Contact information

Lawrence Livermore National Laboratory
7000 East Avenue, L-367
Livermore, CA 94550
email: carpenter36@llnl.gov
phone: 925 422 2900
         
 

Education

Post-doctoral researcher, LLNL (2009-2012)

Ph.D., Biochemistry, University of Oxford (2008)

Masters Biochemistry, University of Oxford (2005)

Research

I am interested in the modeling and biomolecular simulation of integral membrane proteins. Recently I have been focusing on critical neuroreceptors, such as the GABAA receptor and the NMDA and AMPA glutamate receptors.  More info.  Additionally, I have been working on small molecule permeability studies, to investigate the energetic barriers associated with crossing a lipid bilayer. 

Publications

Zhao C., Hwang S.H., Buchholz B.A., Carpenter T.S., Lightstone F.C., Yang J., Hammock B.D., Casida J.E. GABAA receptor target of tetramethylenedisulfotetramine. Proc Natl Acad Sci USA,  111(23): p. 8607-8612.

Carpenter T.S., Lau E.Y., Lightstone F.C. Identification of a Possible Secondary Picrotoxin-Binding Site on the GABAA Receptor. Chem Res Toxicol, 2013. 26(10): p. 1444-54

Carson B., Harmon B., Kozina C., Maar D., Carpenter T.S., Branda C., Negrete O.A. Identification of critical amino acids within the nucleoprotein of Tacaribe virus important for anti-interferon activity. J Biol Chem, 2013. 288(12): p. 8702-11.

Carpenter T.S., Lau E.Y., Lightstone F.C. A role for loop F in modulating GABA binding affinity in the GABA(A) receptor. J Mol Biol, 2012. 422(2): p. 310-23.

Rouse, S.L., Carpenter T., Sansom M.S.P. Coarse-grained Molecular Dynamics Simulations of Membrane Proteins. In Molecular Simulations and Biomembranes: From Biophysics to Function. 2010

Cover image. The Biochemist Magazine. Biochemical Society. 2009. 31(5).

Rouse, S.L.*, Carpenter T.*, Stansfeld, P.J., Sansom M.S.P. Simulations of the BM2 proton channel transmembrane domain from influenza virus B. Biochemistry, 2009. 48(42): p. 9949-51.

Klingelhoefer J.*, Carpenter T.*, Sansom M.S.P. Peptide Nanopores and Lipid Bilayers: Interactions by Coarse-Grained Molecular Dynamics Simulations. Biophys J, 2009. 96(9): p. 3519-28.

Carpenter T., Bond P.J., Khalid S., Sansom M.S.P. Self-Assembly of a Simple Membrane Protein: Coarse Grain Molecular Dynamics Simulations of the Influenza M2 Channel. Biophys J, 2008. 95(8): p. 3790-801.

Khalid S., Bond P.J., Carpenter T., Sansom M.S.P. OmpA: Gating and dynamics via molecular dynamics simulations. Biochim Biophys Acta, 2008. 1778(9): p. 1871-80.

Carpenter T., Khalid S., Sansom M.S.P. A multidomain outer membrane protein from Pasteurella multocida: modelling and simulation studies of PmOmpA. Biochim Biophys Acta. 2007 Nov; 1768(11):2831-40.