Tim Carpenter

Contact information

Lawrence Livermore National Laboratory
7000 East Avenue, L-367
Livermore, CA 94550
email: carpenter36@llnl.gov
phone: 925 422 2900
         
 

Education

Post-doctoral researcher, LLNL (2009-2012)

Ph.D., Biochemistry, University of Oxford (2008)

Masters Biochemistry, University of Oxford (2005)

Research

I am interested in the modeling and biomolecular simulation of integral membrane proteins. Recently I have been focusing on critical neuroreceptors, such as the GABAA receptor and the NMDA and AMPA glutamate receptors.  More info.  Additionally, I have been working on small molecule permeability studies, to investigate the energetic barriers associated with crossing a lipid bilayer. 

Publications

Carpenter T.S., Lau E.Y., Lightstone F.C. Identification of a Possible Secondary Picrotoxin-Binding Site on the GABAA Receptor. Chem Res Toxicol, 2013. 26(10): p. 1444-54

Carson B., Harmon B., Kozina C., Maar D., Carpenter T.S., Branda C., Negrete O.A. Identification of critical amino acids within the nucleoprotein of Tacaribe virus important for anti-interferon activity. J Biol Chem, 2013. 288(12): p. 8702-11.

Carpenter T.S., Lau E.Y., Lightstone F.C. A role for loop F in modulating GABA binding affinity in the GABA(A) receptor. J Mol Biol, 2012. 422(2): p. 310-23.

Rouse, S.L., Carpenter T., Sansom M.S.P. Coarse-grained Molecular Dynamics Simulations of Membrane Proteins. In Molecular Simulations and Biomembranes: From Biophysics to Function. 2010

Cover image. The Biochemist Magazine. Biochemical Society. 2009. 31(5).

Rouse, S.L., Carpenter T., Stansfeld, P.J., Sansom M.S.P. Simulations of the BM2 proton channel transmembrane domain from influenza virus B. Biochemistry, 2009. 48(42): p. 9949-51.

Klingelhoefer J., Carpenter T., Sansom M.S.P. Peptide Nanopores and Lipid Bilayers: Interactions by Coarse-Grained Molecular Dynamics Simulations. Biophys J, 2009. 96(9): p. 3519-28.

Carpenter T., Bond P.J., Khalid S., Sansom M.S.P. Self-Assembly of a Simple Membrane Protein: Coarse Grain Molecular Dynamics Simulations of the Influenza M2 Channel. Biophys J, 2008. 95(8): p. 3790-801.

Khalid S., Bond P.J., Carpenter T., Sansom M.S.P. OmpA: Gating and dynamics via molecular dynamics simulations. Biochim Biophys Acta, 2008. 1778(9): p. 1871-80.

Carpenter T., Khalid S., Sansom M.S.P. A multidomain outer membrane protein from Pasteurella multocida: modelling and simulation studies of PmOmpA. Biochim Biophys Acta. 2007 Nov; 1768(11):2831-40.